منابع مشابه
ASC-particle-induced Peritonitis.
In response to pathogen infection and tissue damage, inflammasome sensors such as NLRP3 and AIM2 are activated, which triggers PYRIN domain (PYD)-mediated ASC nucleation, followed by self-perpetuating ASC polymerization, which ultimately culminates in caspase-1 activation, interleukin (IL)-1β and IL-18 processing and release and pyroptosis (Ratsimandresy et al., 2013; Cai et al., 2014). Inflamm...
متن کاملPyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis
The inflammasome adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via self-oligomerization, which leads to the activation of the protease, caspase-1. Here, we report that the cytosolic tyrosine kinases, FAK and Pyk2, are differentially involved in NLRP3 and AIM2 inflammasome activation. The inhibition of FAK and Pyk2 with RNA interference or chemical i...
متن کاملOuabain Modulates Zymosan-Induced Peritonitis in Mice
Ouabain, a potent inhibitor of the Na(+), K(+)-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes. We have previously demonstrated the ability of ouabain to modulate inflammation, but little is known about the mechanisms involved. Thus, the aim of the present work is to evaluate the immune modulatory role of ouabain on zymosa...
متن کاملABCC transporter inhibition reduces zymosan-induced peritonitis.
Inflammatory mediators are released from injured tissues being responsible for the first steps of inflammatory processes. Multidrug efflux transporters, members of the ATP-binding cassette (ABC) family, are ubiquitously expressed. ABCC molecules transport several endogenous substances, including leukotriene C4 (LTC4) and PGE2, which are involved in zymosan-induced inflammation. The present stud...
متن کاملASC Hoffman.fm
Since the meltdown of the global financial system in 2008 triggered by the sub-prime mortgage bubble in the United States, there is an emerging consensus, even among economists, that there is a need for new economic thinking2 (See Stiglitz, 2010 & Kaletsky, 2010). The economic thinking that has prevailed in postwar capitalist societies is based on the neo-classical – Keynesian synthesis, hereaf...
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ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2016
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.1944